The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for KMT5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KMT5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KMT5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,150,285–123,151,740 | 233.1 kb | Distal (>10kb) Multiome | 487 | |
| chr12:123,232,511–123,233,923 | 151.0 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 114.5 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 112.9 kb | Distal (>10kb) Multiome | 488 | |
| chr12:123,363,804–123,365,980 | 19.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 228 bp | At TSS Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 4.7 kb | Proximal (<10kb) Multiome | 446 | |
| chr12:123,389,470–123,390,035 | 5.3 kb | Proximal (<10kb) | 457 | |
| chr12:123,436,072–123,436,895 | 52.5 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 74.2 kb | Distal (>10kb) Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 149.8 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 200.3 kb | Distal (>10kb) Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 217.9 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 249.6 kb | Distal (>10kb) Multiome | 886 | |
| chr12:123,670,899–123,671,414 | 286.9 kb | Distal (>10kb) Multiome | 469 |
Genomic view of the KMT5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.