Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for KLK8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLK8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLK8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:50,723,765–50,725,772 | 276.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:50,728,202–50,728,738 | 273.1 kb | Distal (>10kb) Multiome | 345 | |
| chr19:50,804,189–50,805,375 | 196.7 kb | Distal (>10kb) Multiome | 919 | |
| chr19:50,835,543–50,836,598 | 165.6 kb | Distal (>10kb) Multiome | 561 | |
| chr19:50,909,047–50,910,046 | 92.1 kb | Distal (>10kb) Multiome | 239 | |
| chr19:50,921,645–50,922,754 | 79.4 kb | Distal (>10kb) Multiome | 450 | |
| chr19:51,001,019–51,001,312 | at TSS | At TSS | 104 | |
| chr19:51,001,594–51,001,828 | 427 bp | At TSS | 52 | |
| chr19:51,002,137–51,003,245 | 1.2 kb | Proximal (<10kb) Multiome | 304 | |
| chr19:51,016,816–51,017,391 | 15.4 kb | Distal (>10kb) Multiome | 394 | |
| chr19:51,064,766–51,065,479 | 63.4 kb | Distal (>10kb) Multiome | 227 | |
| chr19:51,107,794–51,109,056 | 106.8 kb | Distal (>10kb) Multiome | 750 |
Genomic view of the KLK8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.