Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in microtubule cytoskeleton and plasma membrane. Implicated in cocaine dependence. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:38,753,004–38,753,507 | 291.8 kb | Distal (>10kb) Multiome | 401 | |
| chr4:38,867,290–38,868,855 | 177.3 kb | Distal (>10kb) Multiome | 597 | |
| chr4:39,044,055–39,045,485 | 347 bp | At TSS Multiome | 636 | |
| chr4:39,135,136–39,135,640 | 90.4 kb | Distal (>10kb) Multiome | 399 | |
| chr4:39,181,955–39,183,542 | 137.3 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the KLHL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.