Enables cullin family protein binding activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,367,919–84,368,944 | 280.1 kb | Distal (>10kb) Multiome | 287 | |
| chr16:84,504,051–84,505,316 | 143.8 kb | Distal (>10kb) Multiome | 803 | |
| chr16:84,617,446–84,619,117 | 30.4 kb | Distal (>10kb) Multiome | 844 | |
| chr16:84,648,019–84,649,061 | 7 bp | At TSS Multiome | 797 | |
| chr16:84,699,238–84,700,817 | 51.4 kb | Distal (>10kb) Multiome | 876 | |
| chr16:84,819,303–84,820,380 | 171.3 kb | Distal (>10kb) Multiome | 496 | |
| chr16:84,841,652–84,842,331 | 193.5 kb | Distal (>10kb) Multiome | 196 | |
| chr16:84,876,654–84,877,363 | 228.5 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the KLHL36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.