Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:6,392,724–6,394,325 | 209.3 kb | Distal (>10kb) Multiome | 819 | |
| chr1:6,418,998–6,420,339 | 183.1 kb | Distal (>10kb) Multiome | 335 | |
| chr1:6,440,165–6,441,114 | 162.2 kb | Distal (>10kb) Multiome | 215 | |
| chr1:6,446,981–6,449,427 | 155.7 kb | Distal (>10kb) Multiome | 665 | |
| chr1:6,455,053–6,455,773 | 147.5 kb | Distal (>10kb) Multiome | 105 | |
| chr1:6,470,716–6,471,189 | 132.0 kb | Distal (>10kb) Multiome | 148 | |
| chr1:6,471,308–6,471,972 | 131.3 kb | Distal (>10kb) Multiome | 192 | |
| chr1:6,486,194–6,486,953 | 116.2 kb | Distal (>10kb) Multiome | 416 | |
| chr1:6,489,772–6,491,050 | 112.8 kb | Distal (>10kb) Multiome | 676 | |
| chr1:6,497,162–6,497,841 | 105.3 kb | Distal (>10kb) Multiome | 324 | |
| chr1:6,554,053–6,554,774 | 48.3 kb | Distal (>10kb) Multiome | 897 | |
| chr1:6,579,406–6,580,453 | 22.9 kb | Distal (>10kb) Multiome | 684 | |
| chr1:6,600,881–6,601,375 | 1.5 kb | Proximal (<10kb) | 490 | |
| chr1:6,601,460–6,604,144 | 38 bp | At TSS Multiome | 1062 | |
| chr1:6,612,539–6,615,225 | 10.7 kb | Distal (>10kb) Multiome | 806 | |
| chr1:6,624,591–6,625,845 | 22.3 kb | Distal (>10kb) Multiome | 730 | |
| chr1:6,701,304–6,702,223 | 99.0 kb | Distal (>10kb) Multiome | 1025 | |
| chr1:6,784,205–6,786,365 | 182.3 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the KLHL21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.