The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KLHL20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:173,448,455–173,449,477 | 266.1 kb | Distal (>10kb) Multiome | 138 | |
| chr1:173,474,492–173,475,513 | 240.0 kb | Distal (>10kb) Multiome | 348 | |
| chr1:173,476,153–173,478,392 | 237.7 kb | Distal (>10kb) Multiome | 991 | |
| chr1:173,669,068–173,669,991 | 45.2 kb | Distal (>10kb) Multiome | 247 | |
| chr1:173,714,634–173,715,651 | 97 bp | At TSS Multiome | 1013 | |
| chr1:173,824,030–173,825,369 | 109.6 kb | Distal (>10kb) Multiome | 904 | |
| chr1:173,852,512–173,853,711 | 138.1 kb | Distal (>10kb) Multiome | 358 | |
| chr1:173,859,027–173,863,516 | 147.7 kb | Distal (>10kb) Multiome | 578 | |
| chr1:173,866,947–173,869,294 | 153.5 kb | Distal (>10kb) Multiome | 1182 |
Genomic view of the KLHL20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.