The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for KLHL17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:904,256–904,920 | 55.8 kb | Distal (>10kb) Multiome | 590 | |
| chr1:923,612–925,339 | 36.7 kb | Distal (>10kb) Multiome | 500 | |
| chr1:939,835–943,080 | 18.7 kb | Distal (>10kb) Multiome | 864 | |
| chr1:959,035–960,017 | 1.3 kb | Proximal (<10kb) Multiome | 622 | |
| chr1:960,291–961,429 | 169 bp | At TSS Multiome | 552 | |
| chr1:966,272–967,306 | 5.7 kb | Proximal (<10kb) | 594 | |
| chr1:975,960–976,521 | 15.7 kb | Distal (>10kb) Multiome | 476 | |
| chr1:998,350–1,000,999 | 39.8 kb | Distal (>10kb) Multiome | 1047 | |
| chr1:1,001,349–1,002,099 | 41.4 kb | Distal (>10kb) Multiome | 646 | |
| chr1:1,005,015–1,005,702 | 44.7 kb | Distal (>10kb) Multiome | 532 | |
| chr1:1,019,142–1,021,414 | 59.0 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 72.6 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 80.4 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 99.0 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 108.6 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 119.5 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 155.7 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 197.0 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 240.8 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 271.6 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the KLHL17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.