This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for KLHL15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:23,742,772–23,743,685 | 282.0 kb | Distal (>10kb) Multiome | 635 | |
| chrX:23,782,718–23,783,632 | 242.2 kb | Distal (>10kb) Multiome | 741 | |
| chrX:23,907,232–23,908,257 | 117.4 kb | Distal (>10kb) Multiome | 770 | |
| chrX:24,024,718–24,026,097 | 143 bp | At TSS Multiome | 765 | |
| chrX:24,054,185–24,055,227 | 29.3 kb | Distal (>10kb) Multiome | 763 | |
| chrX:24,149,214–24,150,721 | 125.0 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the KLHL15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.