Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nuclear body and nuclear membrane. Is active in Cul2-RING ubiquitin ligase complex and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,585,877–49,587,282 | 181.6 kb | Distal (>10kb) Multiome | 966 | |
| chr14:49,598,179–49,599,418 | 169.3 kb | Distal (>10kb) Multiome | 967 | |
| chr14:49,620,144–49,621,897 | 147.4 kb | Distal (>10kb) Multiome | 930 | |
| chr14:49,633,485–49,635,896 | 133.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr14:49,687,569–49,688,718 | 79.9 kb | Distal (>10kb) Multiome | 843 | |
| chr14:49,692,914–49,693,633 | 74.8 kb | Distal (>10kb) Multiome | 764 | |
| chr14:49,767,002–49,767,333 | 795 bp | At TSS | 111 | |
| chr14:49,767,430–49,769,102 | 108 bp | At TSS Multiome | 899 | |
| chr14:49,852,270–49,853,410 | 84.7 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 85.9 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 94.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr14:49,867,745–49,868,682 | 100.1 kb | Distal (>10kb) Multiome | 699 | |
| chr14:49,892,363–49,894,019 | 124.8 kb | Distal (>10kb) Multiome | 981 | |
| chr14:50,000,183–50,001,939 | 233.2 kb | Distal (>10kb) Multiome | 669 |
Genomic view of the KLHDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.