This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KLC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,075,125–45,076,814 | 264.3 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 260.6 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 247.8 kb | Distal (>10kb) Multiome | 959 | |
| chr19:45,177,803–45,179,711 | 162.3 kb | Distal (>10kb) Multiome | 899 | |
| chr19:45,234,200–45,234,822 | 106.2 kb | Distal (>10kb) Multiome | 105 | |
| chr19:45,250,821–45,251,491 | 89.5 kb | Distal (>10kb) Multiome | 397 | |
| chr19:45,338,709–45,338,925 | 1.8 kb | Proximal (<10kb) | 304 | |
| chr19:45,340,431–45,341,201 | 29 bp | At TSS Multiome | 363 | |
| chr19:45,370,064–45,371,122 | 29.9 kb | Distal (>10kb) Multiome | 592 | |
| chr19:45,402,280–45,402,828 | 61.8 kb | Distal (>10kb) Multiome | 332 | |
| chr19:45,403,781–45,404,684 | 63.2 kb | Distal (>10kb) Multiome | 494 | |
| chr19:45,404,818–45,406,887 | 65.7 kb | Distal (>10kb) Multiome | 964 | |
| chr19:45,423,326–45,424,545 | 83.0 kb | Distal (>10kb) Multiome | 996 | |
| chr19:45,439,539–45,440,189 | 99.1 kb | Distal (>10kb) Multiome | 718 | |
| chr19:45,443,052–45,444,768 | 102.7 kb | Distal (>10kb) Multiome | 857 | |
| chr19:45,450,695–45,451,265 | 110.1 kb | Distal (>10kb) Multiome | 515 | |
| chr19:45,467,169–45,468,696 | 127.0 kb | Distal (>10kb) Multiome | 686 | |
| chr19:45,468,843–45,470,312 | 128.6 kb | Distal (>10kb) Multiome | 769 | |
| chr19:45,478,416–45,479,276 | 138.0 kb | Distal (>10kb) Multiome | 809 | |
| chr19:45,485,144–45,486,070 | 144.8 kb | Distal (>10kb) Multiome | 659 | |
| chr19:45,492,647–45,493,344 | 152.1 kb | Distal (>10kb) Multiome | 522 | |
| chr19:45,496,247–45,497,677 | 156.3 kb | Distal (>10kb) Multiome | 742 | |
| chr19:45,498,270–45,499,916 | 158.8 kb | Distal (>10kb) Multiome | 464 | |
| chr19:45,506,243–45,507,963 | 165.9 kb | Distal (>10kb) Multiome | 969 | |
| chr19:45,508,291–45,509,751 | 167.9 kb | Distal (>10kb) Multiome | 670 | |
| chr19:45,528,315–45,529,353 | 188.1 kb | Distal (>10kb) Multiome | 425 | |
| chr19:45,584,026–45,585,251 | 243.9 kb | Distal (>10kb) Multiome | 907 | |
| chr19:45,607,096–45,607,695 | 266.6 kb | Distal (>10kb) Multiome | 526 | |
| chr19:45,615,654–45,616,944 | 275.4 kb | Distal (>10kb) Multiome | 480 | |
| chr19:45,632,406–45,633,148 | 291.9 kb | Distal (>10kb) Multiome | 358 | |
| chr19:45,638,965–45,639,696 | 298.6 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the KLC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.