Transcription factors with Perturb-seq knockdown data for KIF5C-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF5C-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF5C-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:148,554,358–148,555,153 | 333.7 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr2:148,643,868–148,646,256 | 243.9 kb | Distal (>10kb) Multiome | 1053 | |
| chr2:148,813,520–148,814,415 | 74.6 kb | Distal (>10kb) Multiome | 315 | |
| chr2:148,874,671–148,877,521 | 13.2 kb | Distal (>10kb) Multiome | 652 | |
| chr2:148,887,778–148,888,624 | at TSS | At TSS | 182 | |
| chr2:148,998,911–149,000,002 | 111.0 kb | Distal (>10kb) Multiome | 79 | |
| chr2:149,037,769–149,039,431 | 150.3 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the KIF5C-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.