Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including natural killer cell mediated cytotoxicity; positive regulation of protein localization to plasma membrane; and vesicle transport along microtubule. Located in several cellular components, including centriolar satellite; cytosol; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIF5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:31,758,998–31,760,782 | 296.2 kb | Distal (>10kb) Multiome | 813 | |
| chr10:31,927,740–31,929,636 | 127.7 kb | Distal (>10kb) Multiome | 953 | |
| chr10:32,055,513–32,056,824 | 17 bp | At TSS Multiome | 887 | |
| chr10:32,059,540–32,059,932 | 3.1 kb | Proximal (<10kb) | 259 | |
| chr10:32,150,441–32,151,508 | 94.6 kb | Distal (>10kb) Multiome | 259 | |
| chr10:32,265,752–32,266,479 | 209.5 kb | Distal (>10kb) Multiome | 182 | |
| chr10:32,266,857–32,267,419 | 210.8 kb | Distal (>10kb) Multiome | 101 | |
| chr10:32,345,913–32,347,750 | 290.0 kb | Distal (>10kb) Multiome | 1064 |
Genomic view of the KIF5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.