Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIF3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:25,877,423–25,878,991 | 103.9 kb | Distal (>10kb) Multiome | 984 | |
| chr2:25,912,966–25,913,435 | 69.1 kb | Distal (>10kb) Multiome | 140 | |
| chr2:25,981,827–25,983,286 | 136 bp | At TSS Multiome | 664 | |
| chr2:26,011,658–26,012,446 | 29.6 kb | Distal (>10kb) Multiome | 485 | |
| chr2:26,033,136–26,034,956 | 51.4 kb | Distal (>10kb) Multiome | 1165 | |
| chr2:26,172,352–26,174,365 | 190.5 kb | Distal (>10kb) Multiome | 420 | |
| chr2:26,178,689–26,179,345 | 196.6 kb | Distal (>10kb) Multiome | 245 | |
| chr2:26,179,469–26,180,030 | 197.3 kb | Distal (>10kb) Multiome | 122 | |
| chr2:26,184,159–26,185,510 | 202.4 kb | Distal (>10kb) Multiome | 494 | |
| chr2:26,202,471–26,204,141 | 221.3 kb | Distal (>10kb) Multiome | 38 | |
| chr2:26,244,319–26,245,633 | 262.3 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the KIF3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.