This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for KIF27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,622,459–83,623,894 | 298.3 kb | Distal (>10kb) Multiome | 774 | |
| chr9:83,630,907–83,631,624 | 290.2 kb | Distal (>10kb) Multiome | 194 | |
| chr9:83,706,859–83,708,822 | 214.3 kb | Distal (>10kb) Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 103.7 kb | Distal (>10kb) Multiome | 350 | |
| chr9:83,920,675–83,922,066 | 70 bp | At TSS Multiome | 895 | |
| chr9:83,956,086–83,957,142 | 35.3 kb | Distal (>10kb) Multiome | 869 | |
| chr9:83,979,201–83,981,658 | 59.1 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the KIF27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.