KIF26A
kinesin family member 26A | DKFZP434N178, KIAA1236

Predicted to enable microtubule binding activity. Involved in cerebral cortex development; regulation of neuron migration; and regulation of neuron projection development. Predicted to be located in cytosol. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC7
Biological processes 22 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)cerebral cortex development (GO:0021987)cytoskeleton (GO:0005856)cytosol (GO:0005829)enteric nervous system development (GO:0048484)enteric nervous system development (GO:0048484)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule motor activity (GO:0003777)microtubule-based movement (GO:0007018)negative regulation of signal transduction (GO:0009968)negative regulation of signal transduction (GO:0009968)protein binding (GO:0005515)regulation of cell growth by extracellular stimulus (GO:0001560)regulation of cell growth by extracellular stimulus (GO:0001560)regulation of neuron migration (GO:2001222)regulation of neuron migration (GO:2001222)regulation of neuron projection development (GO:0010975)regulation of neuron projection development (GO:0010975)system development (GO:0048731)
Expression (TPM)
KIF26A — as a Regulated Gene

TFs regulating KIF26A 0 TFs

Transcription factors with Perturb-seq knockdown data for KIF26A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF26A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to KIF26A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF26A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:103,846,809–103,848,686 290.9 kb Distal (>10kb) Multiome 711
chr14:103,855,145–103,855,758 283.0 kb Distal (>10kb) Multiome 418
chr14:103,871,719–103,872,659 266.5 kb Distal (>10kb) Multiome 313
chr14:103,910,266–103,910,793 228.1 kb Distal (>10kb) Multiome 374
chr14:103,921,195–103,921,889 217.0 kb Distal (>10kb) Multiome 874
chr14:104,135,150–104,135,683 769 bp At TSS 141
chr14:104,136,029–104,136,725 2.3 kb Proximal (<10kb) Multiome 125
chr14:104,137,362–104,139,355 901 bp At TSS Multiome 605
chr14:104,149,384–104,150,532 11.5 kb Distal (>10kb) Multiome 371
chr14:104,395,353–104,396,036 257.1 kb Distal (>10kb) Multiome 83
chr14:104,563,886–104,564,429 425.6 kb Distal (>10kb) Multiome HiCAR 258
chr14:104,644,552–104,645,399 506.3 kb Distal (>10kb) Multiome HiCAR 73
chr14:104,650,132–104,650,778 511.9 kb Distal (>10kb) Multiome HiCAR 479

Genome Browser

Genomic view of the KIF26A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:103,836,809 – 104,660,778
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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