The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for KIF16B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF16B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF16B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:16,572,894–16,573,905 | 31 bp | At TSS Multiome | 884 | |
| chr20:16,574,457–16,575,449 | 1.6 kb | Proximal (<10kb) Multiome | 711 | |
| chr20:16,575,568–16,575,874 | 2.2 kb | Proximal (<10kb) | 69 | |
| chr20:16,580,171–16,580,496 | 6.8 kb | Proximal (<10kb) | 177 | |
| chr20:16,623,954–16,625,100 | 50.9 kb | Distal (>10kb) Multiome | 175 | |
| chr20:16,729,453–16,730,497 | 156.6 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the KIF16B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.