This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for KIF13A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF13A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF13A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:17,705,487–17,707,240 | 280.2 kb | Distal (>10kb) Multiome | 1165 | |
| chr6:17,939,336–17,940,066 | 47.3 kb | Distal (>10kb) Multiome | 164 | |
| chr6:17,986,741–17,988,454 | 682 bp | At TSS Multiome | 815 | |
| chr6:18,022,711–18,023,230 | 35.9 kb | Distal (>10kb) Multiome | 195 | |
| chr6:18,122,030–18,123,058 | 135.6 kb | Distal (>10kb) Multiome | 824 | |
| chr6:18,141,867–18,142,341 | 155.0 kb | Distal (>10kb) Multiome | 113 | |
| chr6:18,152,627–18,153,245 | 165.8 kb | Distal (>10kb) Multiome | 199 | |
| chr6:18,154,608–18,156,434 | 168.2 kb | Distal (>10kb) Multiome | 937 | |
| chr6:18,185,739–18,186,332 | 199.0 kb | Distal (>10kb) Multiome | 189 | |
| chr6:18,263,804–18,265,203 | 277.5 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the KIF13A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.