Involved in several processes, including cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Located in intercellular bridge and lysosome. Part of KICSTOR complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for KICS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KICS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KICS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:63,779,430–63,780,603 | 442.3 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr12:63,843,303–63,845,210 | 378.4 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr12:64,218,636–64,219,016 | 3.2 kb | Proximal (<10kb) | 70 | |
| chr12:64,219,281–64,219,535 | 2.7 kb | Proximal (<10kb) | 64 | |
| chr12:64,221,528–64,222,890 | 38 bp | At TSS Multiome | 970 | |
| chr12:64,229,328–64,229,649 | 7.1 kb | Proximal (<10kb) | 44 | |
| chr12:64,390,059–64,390,977 | 168.3 kb | Distal (>10kb) Multiome | 268 | |
| chr12:64,403,794–64,405,423 | 182.1 kb | Distal (>10kb) Multiome | 1007 | |
| chr12:64,451,663–64,452,624 | 229.9 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the KICS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.