Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIAA1614. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA1614 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA1614, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,911,688–180,913,578 | at TSS | At TSS | 364 | |
| chr1:180,922,026–180,922,540 | 9.1 kb | Proximal (<10kb) | 69 | |
| chr1:180,922,741–180,923,870 | 9.8 kb | Proximal (<10kb) | 265 | |
| chr1:180,927,990–180,928,397 | at TSS | At TSS | 75 | |
| chr1:180,933,337–180,933,575 | 5.2 kb | Proximal (<10kb) | 204 |
Genomic view of the KIAA1614 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.