Transcription factors with Perturb-seq knockdown data for KIAA0930. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA0930 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA0930, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:45,006,916–45,010,513 | 230.8 kb | Distal (>10kb) Multiome | 522 | |
| chr22:45,052,140–45,053,598 | 187.9 kb | Distal (>10kb) Multiome | 132 | |
| chr22:45,163,246–45,164,928 | 77.0 kb | Distal (>10kb) Multiome | 938 | |
| chr22:45,239,931–45,241,595 | 106 bp | At TSS Multiome | 482 | |
| chr22:45,267,970–45,269,955 | 28.4 kb | Distal (>10kb) Multiome | 600 | |
| chr22:45,309,117–45,310,833 | 68.9 kb | Distal (>10kb) Multiome | 821 | |
| chr22:45,413,403–45,414,177 | 172.8 kb | Distal (>10kb) Multiome | 453 | |
| chr22:45,435,549–45,435,992 | 194.9 kb | Distal (>10kb) Multiome | 461 | |
| chr22:45,443,959–45,444,454 | 203.4 kb | Distal (>10kb) Multiome | 24 | |
| chr22:45,502,050–45,504,452 | 261.8 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the KIAA0930 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.