Predicted to be involved in several processes, including positive regulation of epidermal cell differentiation; regulation of epidermal cell division; and skin epidermis development. Predicted to act upstream of or within several processes, including keratinocyte development; negative regulation of keratinocyte proliferation; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be active in cell junction. Implicated in ectodermal dysplasia 12. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KDF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,692,203–26,693,499 | 268.0 kb | Distal (>10kb) Multiome | 974 | |
| chr1:26,695,271–26,696,473 | 264.8 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:26,723,135–26,723,892 | 236.9 kb | Distal (>10kb) Multiome | 671 | |
| chr1:26,786,686–26,788,664 | 172.5 kb | Distal (>10kb) Multiome | 918 | |
| chr1:26,826,166–26,827,148 | 133.8 kb | Distal (>10kb) Multiome | 510 | |
| chr1:26,862,775–26,863,565 | 97.5 kb | Distal (>10kb) Multiome | 486 | |
| chr1:26,864,355–26,865,945 | 95.3 kb | Distal (>10kb) Multiome | 892 | |
| chr1:26,889,797–26,890,628 | 70.2 kb | Distal (>10kb) Multiome | 906 | |
| chr1:26,899,986–26,900,610 | 60.1 kb | Distal (>10kb) Multiome | 792 | |
| chr1:26,913,478–26,914,582 | 46.2 kb | Distal (>10kb) Multiome | 877 | |
| chr1:26,921,268–26,922,160 | 38.8 kb | Distal (>10kb) Multiome | 838 | |
| chr1:26,959,908–26,960,855 | 16 bp | At TSS Multiome | 607 | |
| chr1:26,966,989–26,967,180 | 6.5 kb | Proximal (<10kb) | 344 | |
| chr1:26,992,986–26,995,593 | 33.1 kb | Distal (>10kb) Multiome | 854 | |
| chr1:26,997,489–26,998,161 | 37.4 kb | Distal (>10kb) Multiome | 550 | |
| chr1:27,010,686–27,011,820 | 50.7 kb | Distal (>10kb) Multiome | 379 | |
| chr1:27,012,151–27,013,639 | 52.5 kb | Distal (>10kb) Multiome | 712 | |
| chr1:27,031,351–27,031,956 | 71.3 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,102,589–27,103,140 | 142.4 kb | Distal (>10kb) Multiome | 263 | |
| chr1:27,154,381–27,155,711 | 194.6 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:27,233,894–27,235,362 | 274.0 kb | Distal (>10kb) Multiome | 807 |
Genomic view of the KDF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.