Transcription factors with Perturb-seq knockdown data for KCTD21-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD21-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD21-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:76,234,506–76,236,864 | 1903.4 kb | Distal (>10kb) Multiome HiCAR | 965 | |
| chr11:77,994,042–77,995,347 | 144.9 kb | Distal (>10kb) Multiome | 908 | |
| chr11:78,022,454–78,023,411 | 116.6 kb | Distal (>10kb) Multiome | 526 | |
| chr11:78,079,393–78,080,040 | 59.9 kb | Distal (>10kb) Multiome | 1033 | |
| chr11:78,139,106–78,140,207 | 51 bp | At TSS Multiome | 842 | |
| chr11:78,187,536–78,189,464 | 48.9 kb | Distal (>10kb) Multiome | 905 | |
| chr11:78,365,205–78,365,789 | 225.7 kb | Distal (>10kb) Multiome | 332 | |
| chr11:78,416,378–78,418,582 | 278.2 kb | Distal (>10kb) Multiome | 924 |
Genomic view of the KCTD21-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.