Predicted to enable identical protein binding activity. Predicted to be involved in male meiotic nuclear division. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KCTD19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,028,567–67,029,938 | 297.7 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 216.9 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 176.0 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 171.3 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 165.7 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 163.3 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 157.2 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 152.4 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 148.5 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 142.9 kb | Distal (>10kb) Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 141.2 kb | Distal (>10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 134.6 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 127.0 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 99.7 kb | Distal (>10kb) Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 90.0 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 79.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 77.7 kb | Distal (>10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 64.3 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 47.4 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 85 bp | At TSS Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 66.8 kb | Distal (>10kb) Multiome HiCAR | 377 | |
| chr16:67,399,230–67,399,872 | 72.8 kb | Distal (>10kb) Multiome HiCAR | 211 | |
| chr16:67,415,996–67,416,812 | 89.7 kb | Distal (>10kb) Multiome | 687 | |
| chr16:67,428,012–67,428,783 | 101.6 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 104.4 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 154.5 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:67,521,086–67,521,812 | 194.7 kb | Distal (>10kb) Multiome | 775 | |
| chr16:67,528,470–67,529,464 | 202.1 kb | Distal (>10kb) Multiome | 641 | |
| chr16:67,537,215–67,538,620 | 211.3 kb | Distal (>10kb) Multiome | 560 | |
| chr16:67,561,597–67,563,672 | 235.5 kb | Distal (>10kb) Multiome | 1044 |
Genomic view of the KCTD19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.