Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for KCNN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:154,558,123–154,559,826 | 311.4 kb | Distal (>10kb) Multiome HiCAR | 1173 | |
| chr1:154,607,914–154,609,125 | 261.6 kb | Distal (>10kb) Multiome | 720 | |
| chr1:154,627,216–154,628,267 | 242.5 kb | Distal (>10kb) Multiome | 850 | |
| chr1:154,683,607–154,684,346 | 186.3 kb | Distal (>10kb) Multiome | 39 | |
| chr1:154,760,465–154,760,941 | 109.6 kb | Distal (>10kb) Multiome | 418 | |
| chr1:154,813,354–154,814,052 | 56.6 kb | Distal (>10kb) Multiome | 189 | |
| chr1:154,863,716–154,863,863 | 6.4 kb | Proximal (<10kb) | 224 | |
| chr1:154,870,031–154,870,680 | 93 bp | At TSS Multiome | 300 | |
| chr1:154,878,357–154,878,774 | 8.1 kb | Proximal (<10kb) | 366 | |
| chr1:154,936,148–154,937,752 | 66.7 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:154,955,571–154,956,925 | 85.9 kb | Distal (>10kb) Multiome | 504 | |
| chr1:154,961,269–154,962,529 | 91.5 kb | Distal (>10kb) Multiome | 985 | |
| chr1:154,970,161–154,971,641 | 100.6 kb | Distal (>10kb) Multiome | 535 | |
| chr1:154,972,362–154,975,914 | 104.3 kb | Distal (>10kb) Multiome | 1085 | |
| chr1:154,982,968–154,983,632 | 112.9 kb | Distal (>10kb) Multiome | 693 | |
| chr1:154,998,961–155,004,423 | 129.0 kb | Distal (>10kb) Multiome | 1210 | |
| chr1:155,017,084–155,017,941 | 147.2 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:155,050,292–155,052,078 | 181.0 kb | Distal (>10kb) Multiome | 948 | |
| chr1:155,061,415–155,064,552 | 193.6 kb | Distal (>10kb) Multiome | 860 | |
| chr1:155,070,748–155,071,423 | 200.8 kb | Distal (>10kb) Multiome | 542 | |
| chr1:155,078,524–155,079,535 | 208.5 kb | Distal (>10kb) Multiome | 397 | |
| chr1:155,079,852–155,081,529 | 210.7 kb | Distal (>10kb) Multiome | 539 | |
| chr1:155,084,373–155,086,501 | 214.8 kb | Distal (>10kb) Multiome | 865 | |
| chr1:155,091,315–155,091,900 | 221.3 kb | Distal (>10kb) Multiome | 594 | |
| chr1:155,126,247–155,126,903 | 256.2 kb | Distal (>10kb) Multiome | 776 | |
| chr1:155,127,607–155,128,120 | 257.6 kb | Distal (>10kb) Multiome | 578 | |
| chr1:155,135,100–155,136,750 | 265.6 kb | Distal (>10kb) Multiome | 938 | |
| chr1:155,166,847–155,168,170 | 297.5 kb | Distal (>10kb) Multiome | 622 |
Genomic view of the KCNN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.