This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for KCNJ5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNJ5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNJ5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:128,884,618–128,884,998 | 6.4 kb | Proximal (<10kb) | 161 | |
| chr11:128,886,486–128,886,708 | 4.6 kb | Proximal (<10kb) | 59 | |
| chr11:128,888,026–128,888,916 | 2.4 kb | Proximal (<10kb) | 205 | |
| chr11:128,889,641–128,890,137 | 1.2 kb | Proximal (<10kb) | 39 | |
| chr11:128,890,350–128,892,053 | at TSS | At TSS | 360 | |
| chr11:128,894,712–128,894,882 | 3.4 kb | Proximal (<10kb) | 74 |
Genomic view of the KCNJ5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.