This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for KCNIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:170,503,703–170,504,782 | 155 bp | At TSS Multiome | 210 | |
| chr5:170,612,198–170,612,860 | 108.4 kb | Distal (>10kb) Multiome HiCAR | 170 | |
| chr5:170,632,274–170,634,362 | 129.3 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr5:170,638,602–170,639,079 | 134.9 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr5:170,681,011–170,681,468 | 177.3 kb | Distal (>10kb) Multiome | 250 | |
| chr5:170,743,933–170,745,032 | 240.5 kb | Distal (>10kb) Multiome | 466 | |
| chr5:170,745,533–170,746,161 | 242.0 kb | Distal (>10kb) Multiome | 183 | |
| chr5:170,761,207–170,762,213 | 257.6 kb | Distal (>10kb) Multiome | 72 |
Genomic view of the KCNIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.