Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:49,187,732–49,189,017 | 294.2 kb | Distal (>10kb) Multiome | 893 | |
| chr20:49,218,926–49,220,026 | 263.3 kb | Distal (>10kb) Multiome | 836 | |
| chr20:49,277,517–49,279,612 | 204.3 kb | Distal (>10kb) Multiome | 1199 | |
| chr20:49,289,765–49,291,410 | 192.3 kb | Distal (>10kb) Multiome | 436 | |
| chr20:49,482,537–49,483,070 | 226 bp | At TSS Multiome | 732 | |
| chr20:49,483,315–49,484,620 | 1.6 kb | Proximal (<10kb) Multiome | 684 | |
| chr20:49,567,583–49,569,009 | 85.5 kb | Distal (>10kb) Multiome | 251 | |
| chr20:49,610,709–49,611,568 | 128.6 kb | Distal (>10kb) Multiome | 841 | |
| chr20:49,713,090–49,714,241 | 231.3 kb | Distal (>10kb) Multiome | 875 | |
| chr20:49,733,540–49,734,199 | 251.3 kb | Distal (>10kb) Multiome | 15 | |
| chr20:49,762,622–49,763,367 | 280.4 kb | Distal (>10kb) Multiome | 245 |
Genomic view of the KCNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.