Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for KCNAB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNAB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNAB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:5,771,235–5,771,777 | 221.2 kb | Distal (>10kb) Multiome | 90 | |
| chr1:5,980,417–5,980,986 | 12.0 kb | Distal (>10kb) Multiome | 282 | |
| chr1:5,991,687–5,993,712 | 78 bp | At TSS Multiome | 829 | |
| chr1:6,034,542–6,034,743 | at TSS | At TSS | 199 | |
| chr1:6,127,538–6,128,516 | 135.3 kb | Distal (>10kb) Multiome | 300 | |
| chr1:6,148,503–6,149,108 | 156.2 kb | Distal (>10kb) Multiome | 254 | |
| chr1:6,199,148–6,200,364 | 207.1 kb | Distal (>10kb) Multiome | 992 | |
| chr1:6,204,893–6,206,690 | 212.6 kb | Distal (>10kb) Multiome | 913 | |
| chr1:6,208,737–6,209,635 | 216.7 kb | Distal (>10kb) Multiome | 362 | |
| chr1:6,235,160–6,236,710 | 243.4 kb | Distal (>10kb) Multiome | 673 | |
| chr1:6,244,532–6,247,144 | 253.4 kb | Distal (>10kb) Multiome | 1073 | |
| chr1:6,259,688–6,261,954 | 267.5 kb | Distal (>10kb) Multiome | 550 |
Genomic view of the KCNAB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.