Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in neural crest cell development; neural crest formation; and protein monoubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KBTBD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:66,798,002–66,798,599 | 200.0 kb | Distal (>10kb) Multiome | 198 | |
| chr3:66,971,880–66,972,546 | 26.1 kb | Distal (>10kb) Multiome | 371 | |
| chr3:66,988,564–66,989,611 | 9.3 kb | Proximal (<10kb) Multiome | 247 | |
| chr3:66,989,937–66,990,057 | 8.2 kb | Proximal (<10kb) | 60 | |
| chr3:66,997,578–66,999,244 | 95 bp | At TSS Multiome | 661 | |
| chr3:68,931,297–68,933,078 | 1934.3 kb | Distal (>10kb) Multiome HiCAR | 419 |
Genomic view of the KBTBD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.