The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for KBTBD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:40,921,270–40,922,017 | 272.9 kb | Distal (>10kb) Multiome | 675 | |
| chr13:41,060,003–41,062,196 | 132.9 kb | Distal (>10kb) Multiome | 1139 | |
| chr13:41,085,849–41,086,392 | 108.5 kb | Distal (>10kb) Multiome HiCAR | 126 | |
| chr13:41,107,127–41,108,367 | 86.8 kb | Distal (>10kb) Multiome | 291 | |
| chr13:41,132,141–41,133,085 | 61.8 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr13:41,194,020–41,194,940 | 49 bp | At TSS Multiome | 837 | |
| chr13:41,263,241–41,263,968 | 69.1 kb | Distal (>10kb) Multiome | 597 | |
| chr13:41,310,956–41,312,145 | 116.7 kb | Distal (>10kb) Multiome | 855 | |
| chr13:41,456,776–41,458,736 | 262.9 kb | Distal (>10kb) Multiome | 626 |
Genomic view of the KBTBD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.