Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KBTBD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:40,921,270–40,922,017 | 211.2 kb | Distal (>10kb) Multiome | 675 | |
| chr13:41,060,003–41,062,196 | 71.1 kb | Distal (>10kb) Multiome | 1139 | |
| chr13:41,085,849–41,086,392 | 46.7 kb | Distal (>10kb) Multiome | 126 | |
| chr13:41,107,127–41,108,367 | 25.2 kb | Distal (>10kb) Multiome | 291 | |
| chr13:41,132,141–41,133,085 | 3 bp | At TSS Multiome | 774 | |
| chr13:41,194,020–41,194,940 | 61.7 kb | Distal (>10kb) Multiome HiCAR | 837 | |
| chr13:41,263,241–41,263,968 | 130.9 kb | Distal (>10kb) Multiome | 597 | |
| chr13:41,310,956–41,312,145 | 178.6 kb | Distal (>10kb) Multiome | 855 |
Genomic view of the KBTBD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.