Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein K48-linked ubiquitination and regulation of cellular response to insulin stimulus. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KBTBD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:32,727,939–32,729,028 | 163.1 kb | Distal (>10kb) Multiome | 401 | |
| chr7:32,891,014–32,892,877 | 299 bp | At TSS Multiome | 975 | |
| chr7:32,905,220–32,906,208 | 13.9 kb | Distal (>10kb) Multiome | 394 | |
| chr7:32,942,280–32,943,451 | 51.3 kb | Distal (>10kb) Multiome | 800 | |
| chr7:32,956,900–32,958,942 | 65.8 kb | Distal (>10kb) Multiome | 933 | |
| chr7:33,062,109–33,063,556 | 171.2 kb | Distal (>10kb) Multiome | 912 | |
| chr7:33,108,633–33,110,110 | 217.7 kb | Distal (>10kb) Multiome | 702 | |
| chr7:33,128,895–33,130,093 | 237.6 kb | Distal (>10kb) Multiome | 726 |
Genomic view of the KBTBD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.