Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for KATNA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KATNA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KATNA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:149,431,999–149,432,482 | 216.5 kb | Distal (>10kb) Multiome | 527 | |
| chr6:149,545,230–149,546,831 | 102.6 kb | Distal (>10kb) Multiome | 1020 | |
| chr6:149,565,581–149,567,238 | 82.5 kb | Distal (>10kb) Multiome | 1021 | |
| chr6:149,648,112–149,649,264 | 13 bp | At TSS Multiome | 1051 | |
| chr6:149,708,994–149,710,258 | 60.9 kb | Distal (>10kb) Multiome | 141 | |
| chr6:149,717,353–149,718,457 | 69.3 kb | Distal (>10kb) Multiome | 1074 | |
| chr6:149,746,178–149,746,876 | 97.8 kb | Distal (>10kb) Multiome | 812 | |
| chr6:149,749,354–149,750,638 | 101.0 kb | Distal (>10kb) Multiome | 967 | |
| chr6:149,845,261–149,846,647 | 197.1 kb | Distal (>10kb) Multiome | 234 | |
| chr6:149,863,201–149,865,192 | 214.6 kb | Distal (>10kb) Multiome | 906 | |
| chr6:149,922,648–149,923,559 | 274.5 kb | Distal (>10kb) Multiome | 419 | |
| chr6:149,925,530–149,926,657 | 277.6 kb | Distal (>10kb) Multiome | 390 | |
| chr6:149,941,434–149,942,626 | 293.2 kb | Distal (>10kb) Multiome | 476 |
Genomic view of the KATNA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.