The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KAT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,416,383–65,417,015 | 295.7 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 293.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 289.8 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 257.1 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 234.7 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 224.5 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 214.7 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,506,702–65,508,865 | 205.0 kb | Distal (>10kb) Multiome | 864 | |
| chr11:65,524,475–65,525,724 | 187.2 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 171.4 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 165.6 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 158.6 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 142.0 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 139.8 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 137.9 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,575,601–65,576,322 | 136.2 kb | Distal (>10kb) Multiome | 527 | |
| chr11:65,591,808–65,592,698 | 120.0 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 105.1 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 98.1 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 96.7 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 74.1 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 70.1 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 65.0 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 59.5 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 49.2 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,706,324–65,706,528 | 5.7 kb | Proximal (<10kb) | 79 | |
| chr11:65,709,683–65,709,957 | 2.3 kb | Proximal (<10kb) | 47 | |
| chr11:65,711,437–65,712,942 | 30 bp | At TSS Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 8.4 kb | Proximal (<10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 67.8 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 76.2 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 106.0 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 121.5 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 144.8 kb | Distal (>10kb) Multiome HiCAR | 972 | |
| chr11:65,859,034–65,861,240 | 148.4 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 161.5 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 176.3 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 178.4 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 188.3 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 207.0 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 249.4 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 290.2 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 295.2 kb | Distal (>10kb) Multiome | 100 |
Genomic view of the KAT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.