Predicted to be involved in positive regulation of DNA-templated transcription. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of NSL complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KANSL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KANSL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KANSL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:48,681,532–48,682,844 | 47 bp | At TSS Multiome | 933 | |
| chr12:48,716,299–48,717,435 | 34.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:48,788,600–48,789,901 | 107.1 kb | Distal (>10kb) Multiome | 478 | |
| chr12:48,795,703–48,796,330 | 113.8 kb | Distal (>10kb) Multiome | 333 | |
| chr12:48,814,087–48,815,981 | 132.6 kb | Distal (>10kb) Multiome | 815 | |
| chr12:48,817,927–48,819,273 | 136.3 kb | Distal (>10kb) Multiome | 459 | |
| chr12:48,851,862–48,852,825 | 170.0 kb | Distal (>10kb) Multiome | 900 | |
| chr12:48,864,974–48,866,292 | 183.7 kb | Distal (>10kb) Multiome | 649 | |
| chr12:48,883,231–48,884,168 | 201.5 kb | Distal (>10kb) Multiome | 433 | |
| chr12:48,890,671–48,891,380 | 208.7 kb | Distal (>10kb) Multiome | 517 | |
| chr12:48,924,659–48,925,688 | 242.7 kb | Distal (>10kb) Multiome | 413 | |
| chr12:48,956,252–48,957,974 | 274.3 kb | Distal (>10kb) Multiome | 831 | |
| chr12:48,978,055–48,978,819 | 296.0 kb | Distal (>10kb) Multiome | 360 | |
| chr12:48,980,647–48,981,153 | 298.7 kb | Distal (>10kb) Multiome | 259 |
Genomic view of the KANSL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.