Predicted to be involved in axoneme assembly and brain development. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; motile cilium assembly; and regulation of establishment of planar polarity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for JHY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JHY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JHY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:122,655,417–122,657,184 | 227.0 kb | Distal (>10kb) Multiome | 620 | |
| chr11:122,843,093–122,844,055 | 39.3 kb | Distal (>10kb) Multiome | 284 | |
| chr11:122,882,666–122,883,545 | 327 bp | At TSS Multiome | 409 | |
| chr11:122,981,561–122,982,103 | 99.2 kb | Distal (>10kb) Multiome | 237 | |
| chr11:123,061,397–123,063,188 | 179.7 kb | Distal (>10kb) Multiome | 997 | |
| chr11:123,108,059–123,109,666 | 226.5 kb | Distal (>10kb) Multiome | 58 | |
| chr11:123,166,097–123,166,614 | 283.5 kb | Distal (>10kb) Multiome | 131 | |
| chr11:123,168,860–123,170,139 | 287.2 kb | Distal (>10kb) Multiome | 127 |
Genomic view of the JHY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.