The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]
Transcription factors with Perturb-seq knockdown data for JAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:10,433,347–10,435,565 | 239.7 kb | Distal (>10kb) Multiome | 1181 | |
| chr20:10,637,187–10,638,013 | 36.3 kb | Distal (>10kb) Multiome | 259 | |
| chr20:10,664,452–10,664,714 | 9.3 kb | Proximal (<10kb) | 144 | |
| chr20:10,671,001–10,671,242 | 2.8 kb | Proximal (<10kb) | 237 | |
| chr20:10,671,398–10,673,077 | 2.2 kb | Proximal (<10kb) Multiome | 949 | |
| chr20:10,673,196–10,675,289 | 148 bp | At TSS Multiome | 1034 |
Genomic view of the JAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.