JADE2
jade family PHD finger 2 | JADE-2, KIAA0239, PHF15

Enables histone H4K12 acetyltransferase activity; histone H4K5 acetyltransferase activity; and histone H4K8 acetyltransferase activity. Contributes to histone H3K14 acetyltransferase activity. Involved in regulation of DNA biosynthetic process; regulation of DNA replication; and regulation of cell cycle. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC5
Biological processes 23 terms
chromatin remodeling (GO:0006338)extracellular exosome (GO:0070062)histone H3K14 acetyltransferase activity (GO:0036408)histone H4K12 acetyltransferase activity (GO:0043997)histone H4K16 acetyltransferase activity (GO:0046972)histone H4K5 acetyltransferase activity (GO:0043995)histone H4K8 acetyltransferase activity (GO:0043996)histone acetyltransferase complex (GO:0000123)histone acetyltransferase complex (GO:0000123)histone acetyltransferase complex (GO:0000123)histone reader activity (GO:0140566)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)protein ubiquitination (GO:0016567)regulation of DNA biosynthetic process (GO:2000278)regulation of DNA biosynthetic process (GO:2000278)regulation of DNA replication (GO:0006275)regulation of DNA replication (GO:0006275)regulation of cell cycle (GO:0051726)regulation of cell cycle (GO:0051726)regulation of transcription by RNA polymerase II (GO:0006357)ubiquitin protein ligase activity (GO:0061630)
Expression (TPM)
JADE2 — as a Regulated Gene

TFs regulating JADE2 0 TFs

Transcription factors with Perturb-seq knockdown data for JADE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JADE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to JADE2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JADE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:134,225,248–134,227,248 298.1 kb Distal (>10kb) Multiome 1043
chr5:134,366,722–134,367,362 157.1 kb Distal (>10kb) Multiome HiCAR 682
chr5:134,370,722–134,372,303 153.0 kb Distal (>10kb) Multiome HiCAR 1080
chr5:134,411,465–134,412,433 112.4 kb Distal (>10kb) Multiome HiCAR 989
chr5:134,465,626–134,467,213 58.4 kb Distal (>10kb) Multiome HiCAR 926
chr5:134,506,114–134,506,990 18.0 kb Distal (>10kb) Multiome 644
chr5:134,511,761–134,512,800 12.0 kb Distal (>10kb) Multiome 505
chr5:134,523,964–134,528,361 3.3 kb Proximal (<10kb) Multiome 1077
chr5:134,539,671–134,540,206 15.6 kb Distal (>10kb) Multiome 144
chr5:134,586,828–134,587,543 62.9 kb Distal (>10kb) Multiome HiCAR 407
chr5:134,632,348–134,633,007 108.5 kb Distal (>10kb) Multiome 1019
chr5:134,648,377–134,649,305 124.5 kb Distal (>10kb) Multiome 995
chr5:134,737,780–134,739,410 214.1 kb Distal (>10kb) Multiome 1014
chr5:134,758,294–134,759,262 234.4 kb Distal (>10kb) Multiome 1011

Genome Browser

Genomic view of the JADE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:134,215,248 – 134,769,262
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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