Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IVNS1ABP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IVNS1ABP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IVNS1ABP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:185,044,828–185,046,417 | 271.9 kb | Distal (>10kb) Multiome | 816 | |
| chr1:185,156,218–185,158,419 | 160.1 kb | Distal (>10kb) Multiome | 949 | |
| chr1:185,315,737–185,318,408 | 230 bp | At TSS Multiome | 1078 | |
| chr1:185,733,419–185,734,967 | 417.0 kb | Distal (>10kb) Multiome HiCAR | 587 | |
| chr1:186,374,421–186,376,214 | 1058.3 kb | Distal (>10kb) Multiome HiCAR | 1064 |
Genomic view of the IVNS1ABP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.