Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ITPRIPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPRIPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPRIPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:18,925,547–18,927,198 | 187.4 kb | Distal (>10kb) Multiome | 788 | |
| chr16:18,983,732–18,984,444 | 130.0 kb | Distal (>10kb) Multiome | 817 | |
| chr16:19,067,380–19,068,213 | 46.2 kb | Distal (>10kb) Multiome | 982 | |
| chr16:19,086,334–19,086,896 | 27.3 kb | Distal (>10kb) Multiome | 852 | |
| chr16:19,113,633–19,114,626 | 115 bp | At TSS Multiome | 801 | |
| chr16:19,114,949–19,115,338 | 1.0 kb | Proximal (<10kb) | 283 | |
| chr16:19,167,649–19,168,727 | 54.0 kb | Distal (>10kb) Multiome | 572 | |
| chr16:19,299,373–19,300,029 | 185.8 kb | Distal (>10kb) Multiome | 136 | |
| chr16:19,348,618–19,349,340 | 235.1 kb | Distal (>10kb) Multiome | 189 | |
| chr16:19,410,445–19,411,161 | 296.8 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the ITPRIPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.