Enables receptor ligand activity. Involved in negative regulation of T cell receptor signaling pathway. Located in membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ITPRIPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPRIPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPRIPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,116,133–96,117,547 | 208.5 kb | Distal (>10kb) Multiome | 470 | |
| chr2:96,138,522–96,139,006 | 186.6 kb | Distal (>10kb) Multiome | 255 | |
| chr2:96,144,225–96,145,701 | 179.9 kb | Distal (>10kb) Multiome | 423 | |
| chr2:96,148,417–96,148,969 | 176.6 kb | Distal (>10kb) Multiome | 318 | |
| chr2:96,207,850–96,209,429 | 116.4 kb | Distal (>10kb) Multiome | 1022 | |
| chr2:96,265,014–96,266,655 | 59.2 kb | Distal (>10kb) Multiome | 992 | |
| chr2:96,305,302–96,305,947 | 19.7 kb | Distal (>10kb) Multiome | 918 | |
| chr2:96,321,245–96,322,149 | 3.5 kb | Proximal (<10kb) Multiome | 640 | |
| chr2:96,325,023–96,325,881 | 60 bp | At TSS Multiome | 443 | |
| chr2:96,335,437–96,336,197 | 10.6 kb | Distal (>10kb) Multiome | 847 | |
| chr2:96,507,900–96,508,563 | 182.9 kb | Distal (>10kb) Multiome | 466 | |
| chr2:96,509,253–96,509,998 | 184.3 kb | Distal (>10kb) Multiome | 525 | |
| chr2:96,531,989–96,532,491 | 207.0 kb | Distal (>10kb) Multiome | 500 | |
| chr2:96,536,180–96,538,128 | 211.3 kb | Distal (>10kb) Multiome | 684 | |
| chr2:96,538,413–96,539,012 | 213.4 kb | Distal (>10kb) Multiome | 371 | |
| chr2:96,554,285–96,554,861 | 229.3 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the ITPRIPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.