This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for ITPRIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPRIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPRIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:104,045,227–104,046,125 | 292.9 kb | Distal (>10kb) Multiome | 116 | |
| chr10:104,057,535–104,058,241 | 280.5 kb | Distal (>10kb) Multiome | 66 | |
| chr10:104,120,766–104,122,782 | 216.5 kb | Distal (>10kb) Multiome | 959 | |
| chr10:104,155,284–104,156,268 | 182.6 kb | Distal (>10kb) Multiome | 175 | |
| chr10:104,231,576–104,232,903 | 106.1 kb | Distal (>10kb) Multiome | 777 | |
| chr10:104,252,389–104,254,221 | 85.1 kb | Distal (>10kb) Multiome | 583 | |
| chr10:104,254,370–104,255,379 | 83.6 kb | Distal (>10kb) Multiome | 714 | |
| chr10:104,268,486–104,269,500 | 69.4 kb | Distal (>10kb) Multiome | 569 | |
| chr10:104,274,546–104,275,629 | 63.5 kb | Distal (>10kb) Multiome | 513 | |
| chr10:104,291,224–104,291,975 | 46.9 kb | Distal (>10kb) Multiome | 512 | |
| chr10:104,305,412–104,306,052 | 32.7 kb | Distal (>10kb) Multiome | 394 | |
| chr10:104,323,140–104,323,496 | 5.4 kb | Proximal (<10kb) | 23 | |
| chr10:104,328,024–104,329,489 | 9.6 kb | Proximal (<10kb) Multiome HiCAR | 537 | |
| chr10:104,331,220–104,332,050 | 6.9 kb | Proximal (<10kb) Multiome | 374 | |
| chr10:104,332,513–104,332,700 | 3.6 kb | Proximal (<10kb) | 123 | |
| chr10:104,333,107–104,333,747 | 4.2 kb | Proximal (<10kb) | 119 | |
| chr10:104,336,968–104,337,247 | 8.0 kb | Proximal (<10kb) | 123 | |
| chr10:104,337,560–104,339,351 | 25 bp | At TSS Multiome | 762 | |
| chr10:104,353,170–104,354,177 | 15.2 kb | Distal (>10kb) Multiome | 470 | |
| chr10:104,473,780–104,474,540 | 135.5 kb | Distal (>10kb) Multiome | 58 | |
| chr10:104,496,707–104,497,286 | 158.6 kb | Distal (>10kb) Multiome | 14 |
Genomic view of the ITPRIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.