Enables actin filament binding activity. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ITPRID2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPRID2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPRID2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:181,656,181–181,658,869 | 234.1 kb | Distal (>10kb) Multiome | 546 | |
| chr2:181,677,659–181,678,624 | 213.5 kb | Distal (>10kb) Multiome | 585 | |
| chr2:181,680,198–181,681,989 | 211.0 kb | Distal (>10kb) Multiome | 316 | |
| chr2:181,682,538–181,684,472 | 208.0 kb | Distal (>10kb) Multiome | 355 | |
| chr2:181,803,820–181,804,716 | 87.5 kb | Distal (>10kb) Multiome | 318 | |
| chr2:181,891,152–181,892,949 | 83 bp | At TSS Multiome | 1077 | |
| chr2:181,900,079–181,900,478 | 8.3 kb | Proximal (<10kb) | 89 |
Genomic view of the ITPRID2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.