The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ITPKB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITPKB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITPKB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:226,548,271–226,549,075 | 190.5 kb | Distal (>10kb) Multiome | 269 | |
| chr1:226,608,563–226,609,002 | 130.5 kb | Distal (>10kb) Multiome | 148 | |
| chr1:226,679,874–226,680,709 | 59.1 kb | Distal (>10kb) Multiome | 422 | |
| chr1:226,736,695–226,739,072 | 1.9 kb | Proximal (<10kb) Multiome | 426 | |
| chr1:226,824,867–226,826,112 | 85.9 kb | Distal (>10kb) Multiome HiCAR | 167 | |
| chr1:226,827,950–226,828,394 | 88.9 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr1:226,870,257–226,871,262 | 131.3 kb | Distal (>10kb) Multiome HiCAR | 692 | |
| chr1:226,939,374–226,940,917 | 200.8 kb | Distal (>10kb) Multiome | 1091 | |
| chr1:226,944,823–226,946,056 | 206.3 kb | Distal (>10kb) Multiome | 574 |
Genomic view of the ITPKB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.