The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ITGB1BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGB1BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGB1BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,142,361–9,143,365 | 280.7 kb | Distal (>10kb) Multiome HiCAR | 712 | |
| chr2:9,177,942–9,178,829 | 245.1 kb | Distal (>10kb) Multiome | 196 | |
| chr2:9,205,968–9,208,238 | 216.8 kb | Distal (>10kb) Multiome | 800 | |
| chr2:9,218,015–9,218,554 | 205.4 kb | Distal (>10kb) Multiome | 107 | |
| chr2:9,422,555–9,424,057 | 11 bp | At TSS Multiome | 1016 | |
| chr2:9,473,505–9,475,238 | 51.2 kb | Distal (>10kb) Multiome | 602 | |
| chr2:9,475,498–9,477,288 | 53.2 kb | Distal (>10kb) Multiome | 228 | |
| chr2:9,554,934–9,556,567 | 132.3 kb | Distal (>10kb) Multiome | 1091 | |
| chr2:9,630,002–9,631,663 | 207.5 kb | Distal (>10kb) Multiome | 995 |
Genomic view of the ITGB1BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.