The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for ITGA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:49,763,285–49,764,743 | 291.7 kb | Distal (>10kb) Multiome | 768 | |
| chr17:49,788,330–49,789,442 | 266.8 kb | Distal (>10kb) Multiome | 1068 | |
| chr17:49,851,098–49,852,060 | 204.1 kb | Distal (>10kb) Multiome | 614 | |
| chr17:49,865,367–49,866,210 | 190.2 kb | Distal (>10kb) Multiome | 213 | |
| chr17:49,880,287–49,880,820 | 175.3 kb | Distal (>10kb) Multiome | 493 | |
| chr17:49,910,218–49,910,854 | 145.3 kb | Distal (>10kb) Multiome | 230 | |
| chr17:49,968,328–49,969,629 | 86.9 kb | Distal (>10kb) Multiome | 702 | |
| chr17:49,993,266–49,993,947 | 62.4 kb | Distal (>10kb) Multiome | 222 | |
| chr17:49,994,638–49,995,383 | 60.8 kb | Distal (>10kb) Multiome | 281 | |
| chr17:50,055,064–50,055,381 | 585 bp | At TSS | 163 | |
| chr17:50,055,522–50,057,280 | 813 bp | At TSS Multiome | 654 | |
| chr17:50,094,331–50,095,951 | 39.3 kb | Distal (>10kb) Multiome | 899 | |
| chr17:50,117,038–50,117,876 | 61.5 kb | Distal (>10kb) Multiome | 488 | |
| chr17:50,150,777–50,152,506 | 95.1 kb | Distal (>10kb) Multiome | 900 | |
| chr17:50,161,052–50,162,135 | 105.7 kb | Distal (>10kb) Multiome | 691 | |
| chr17:50,177,880–50,178,665 | 122.4 kb | Distal (>10kb) Multiome | 675 | |
| chr17:50,199,586–50,201,292 | 144.5 kb | Distal (>10kb) Multiome | 798 | |
| chr17:50,273,066–50,273,646 | 217.3 kb | Distal (>10kb) Multiome | 411 | |
| chr17:50,274,084–50,274,945 | 218.5 kb | Distal (>10kb) Multiome | 242 | |
| chr17:50,345,523–50,346,998 | 290.2 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the ITGA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.