Predicted to be involved in positive regulation of axon extension. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ISLR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ISLR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ISLR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:73,926,301–73,928,142 | 201.7 kb | Distal (>10kb) Multiome | 557 | |
| chr15:73,964,793–73,965,395 | 163.1 kb | Distal (>10kb) Multiome | 395 | |
| chr15:73,972,958–73,973,626 | 154.9 kb | Distal (>10kb) Multiome | 375 | |
| chr15:73,991,853–73,992,729 | 135.8 kb | Distal (>10kb) Multiome | 723 | |
| chr15:73,994,310–73,995,392 | 133.4 kb | Distal (>10kb) Multiome | 539 | |
| chr15:74,124,047–74,124,500 | 3.6 kb | Proximal (<10kb) | 16 | |
| chr15:74,127,396–74,128,614 | 380 bp | At TSS Multiome | 498 | |
| chr15:74,129,520–74,130,600 | 2.0 kb | Proximal (<10kb) Multiome | 188 | |
| chr15:74,134,110–74,134,917 | 6.4 kb | Proximal (<10kb) Multiome | 220 | |
| chr15:74,135,992–74,136,743 | 8.3 kb | Proximal (<10kb) Multiome | 439 | |
| chr15:74,202,453–74,203,387 | 74.8 kb | Distal (>10kb) Multiome | 381 | |
| chr15:74,208,748–74,209,470 | 81.0 kb | Distal (>10kb) Multiome | 233 | |
| chr15:74,291,174–74,291,950 | 163.4 kb | Distal (>10kb) Multiome | 773 | |
| chr15:74,365,599–74,366,233 | 237.8 kb | Distal (>10kb) Multiome | 441 | |
| chr15:74,373,469–74,375,034 | 246.3 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the ISLR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.