Predicted to enable signaling adaptor activity. Predicted to be involved in canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for IRAK1BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRAK1BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRAK1BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:77,650,043–77,650,891 | 1217.1 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr6:78,628,943–78,630,053 | 238.1 kb | Distal (>10kb) Multiome | 215 | |
| chr6:78,867,149–78,868,108 | 122 bp | At TSS Multiome | 844 | |
| chr6:78,910,172–78,911,412 | 43.3 kb | Distal (>10kb) Multiome | 216 | |
| chr6:79,076,747–79,078,922 | 209.5 kb | Distal (>10kb) Multiome | 1020 | |
| chr6:79,151,998–79,152,949 | 284.9 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the IRAK1BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.