Enables Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IQCG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQCG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQCG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:197,736,285–197,737,626 | 223.0 kb | Distal (>10kb) Multiome | 760 | |
| chr3:197,749,348–197,750,809 | 210.3 kb | Distal (>10kb) Multiome | 787 | |
| chr3:197,790,656–197,791,971 | 168.7 kb | Distal (>10kb) Multiome | 906 | |
| chr3:197,949,736–197,950,528 | 9.9 kb | Proximal (<10kb) Multiome | 803 | |
| chr3:197,957,094–197,957,550 | 7.2 kb | Proximal (<10kb) | 391 | |
| chr3:197,959,834–197,960,964 | 198 bp | At TSS Multiome | 773 | |
| chr3:198,080,117–198,081,882 | 120.9 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the IQCG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.