This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for IPMK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IPMK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IPMK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:58,050,151–58,051,097 | 217.2 kb | Distal (>10kb) Multiome | 130 | |
| chr10:58,140,507–58,141,288 | 126.9 kb | Distal (>10kb) Multiome | 122 | |
| chr10:58,266,789–58,269,963 | 21 bp | At TSS Multiome | 1224 | |
| chr10:58,276,058–58,276,258 | 8.2 kb | Proximal (<10kb) | 41 | |
| chr10:58,334,610–58,335,934 | 67.1 kb | Distal (>10kb) Multiome | 801 | |
| chr10:58,384,591–58,386,114 | 117.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr10:58,512,205–58,513,965 | 245.1 kb | Distal (>10kb) Multiome | 523 |
Genomic view of the IPMK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.